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作者: 编辑:李贵叶-健康学院 审核人: 发布时间:2023-06-07 09:48 来源: 点击量:

个人简介

副教授,孔雀人才

研究方向:微纳米制备生物医学工程器件、纳米医药、药物递送

教育及工作经历:

2010年四川大学,生物医学工程专业,本科;2011-2015年,香港城市大学,超金刚石与先进薄膜中心(COSDAF)获得博士学位;先后任职于成都大学、国药集团四川抗菌素工业研究所以及澳大利亚蒙纳士大学药学院;于2020年入职深圳技术大学,健康与环境工程学院,任助理教授;于2022年12月晋升为副教授。

主持或参与的基金项目:

1、国家自然科学基金青年基金;

2、深圳市高层次引进人才启动项目。

代表著作:

1Yan L., Chen X. Chapter 7 - Nanomaterials for Drug Delivery. In SC Tjong (ed.), Nanocrystalline Materials (Second Edition) Oxford: Elsevier; 2014. p. 221-268.

代表专利:

1Yan L. and Chen X., Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery. US Patent 9526884, published on 27 Dec 2016. PRC Patent, CN 201310573710.

代表文章:

1Yan L., Gopal A., Kashif S., Hazelton P., Lan M.H.*, Zhang W.J.*, Chen X.F.* Metal organic frameworks for antibacterial applications. Chemical Engineering Journal, 2022, 435, 134975.

2Liu J.X.#, Yan L.#, He S.L., Hu J.* Engineering DNA quadruplexes in DNA nanostructures for biosensor construction. Nano Research, 2022, 15, 3504.

3Yan L.*, Li J., Gopal A., Roberts S.C., Lin J.F., Liu T.T., Munshi T., Zhang X.J., Chen X.F. Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria. Mater. Today Commun., 2022, 30, 103101.

4Zhao S.,# Yan L.,# Cao M.,# Huang L., Yang K., Wu S., Lan M.,* Niu G., Zhang W.J.* Near-Infrared Light-Triggered Lysosome-Targetable Carbon Dots for Photothermal Therapy of Cancer. ACS Applied Materials & Interfaces 2021, 13, 53610-53617.

5Peng X., Ai F., Yan L.*, Ha E., Hu X., He S., Hu J.* Doped inorganic semiconductor nanocrystals: synthesis strategies and biomedical applications. Cell Reports Physical Science, 2021, 2, 100436.

6Chen Y., Gao M., Zhang L., Ha E., Hu X., Zou R.*, Yan L.*, Hu J.* Tumor Microenvironment responsive biodegradable Fe-Doped MoOx nanowires for magnetic resonance imaging guided photothermal enhanced chemodynamic synergistic antitumor therapy. Advanced Healthcare Materials, 2021, 2001665.

7Li J., Gopal A., Karaosmanoglu S., Lin J., Munshi T., Zhang W.,* Chen X.,* Yan L.* Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA). Colloid and Surfaces B: Biointerfaces 2020, 110900.

8Yan L., Alba M.,* Tabassum N., Voelcker N.H.* Micro- and nanosystems for advanced transdermal delivery. Advanced Therapeutics 2019, 201900141.

9Yan L., Gonca S., Zhu G., Zhang W., Chen X.* Layered double hydroxide nanostructures and nanocomposites for biomedical applications. Journal of Materials Chemistry B 2019, 5583-5601.

10Lin J., Li J., Gopal A., Munshi T., Chu Y., Wang J., Liu T., Shi B., Chen X.*, Yan L.* Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus. Chemical Communications 2019; 55:2656-2659.

11Yan L., Zhou M., Zhang X., Huang L., Chen W., Roy V.A.L., Zhang W., Chen X. A novel type of aqueous dispersible ultrathin layered double hydroxide nanosheets for in vivo bioimaging and drug delivery. ACS Applied Materials & Interfaces 2017; 9:34185-34193.

12Yan L., Chen X., Wang Z., Zhang X., Zhu X., Zhou M., Chen W., Huang L., Roy V.A.L., Yu P.K.N., Zhu G., Zhang W. Size controllable and surface tunable zeolitic imidazolate framework-8 (ZIF-8)-poly(acrylic acid sodium salt) (PAAS) nanocomposites for pH responsive frug release and enhanced in vivo cancer treatment. ACS Applied Materials & Interfaces 2017; 9:32990-33000.

13Yan L., Wang Z., Chen X., Guo X., Zhang Z., Zhu X., Lan M., Chen W., Zhu G., Zhang W. Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo. Chemical Communications 2017; 53: 2339-2342.

14Yan L., Yang Y., Zhang W., Chen X. Advanced materials and nanotechnology for drug delivery. Advanced Materials 2014; 26:5533-5540.

15Yan L., Raphael A.P., Zhu X., Wang B., Chen W., Tang T., Deng Y., Sant H.J., Zhu G., Choy K.W., Gale B.K., Prow T., Chen X. Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin. Advanced Healthcare Materials 2014; 3:555-564.

16Yan L., Zhang J., Lee C., Chen X. Micro- and nanotechnologies for intracellular delivery. Small 2014; 10:4487-4504.

17Yan L., Wang Y., Li J., Kalytchuk S., Susha A.S., Kershaw S.V., Yan Feng, Rogach A.L., Chen X. Highly luminescent covalently bonded double hydroxide nanoparticle-fluorescent dye nanohybrids. Journal of Materials Chemistry C 2014; 2:4490-4494.

18Yan L., Chen W., Zhu X., Huang L., Wang Z., Zhu G., Roy V.A.L., Chen X. Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery. Chemical Communications 2013; 49(93):10938-10940.

联系方式:yanli@sztu.edu.cn

 

 

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