个人简介
研究方向：
蛋白质组学技术开发及应用
多肽自组装材料研究及生物医学应用
新型纳米医药分子开发
教育及工作经历：
2024年7月至今 助理教授 深圳技术大学
2023年4月-2024年6月 副研究员 深圳技术大学
2018年9月-2023年3月 博士后&助理研究员 北京大学深圳研究生院
2012年9月-2018年6月 博士 中国农业大学&美国西北太平洋国家实验室
2008年9月-2012年6月 本科 中国农业大学
主持的基金项目：
(1)国家自然科学基金委员会,青年科学基金项目。
(2)深圳市科技创新局,基础研究（面上项目）。
(3)深圳市科技创新委员会,基础研究（重点项目）（合作单位负责人）。
(4)广东省基础与应用基础研究基金委员会,区域联合基金-青年基金项目。
代表论文：
1.Yang, D.; Ruan, Z.; He, S.; Tang, L.; Wang, R.*;Wan, C.(*), Sulfur(IV) Chemistry-Based Peptide and Protein Late-Stage Modification.ChemBioChem2025, 26, e202500234.
2.Chuan Wan(#), Yichi Zhang(#), Jinpeng Wang, Yun Xing, Dongyan Yang, Qinhong Luo, Jianbo Liu, Yuxin Ye, Zhihong Liu, Feng Yin(*), Rui Wang(*), and Zigang Li(*). Traceless Peptide and Protein ModificationviaRational Tuning of Pyridiniums,J. Am. Chem. Soc.2024, 146, 2624−2633.
3.Wan, C.(# *); Yang, D.(#); An, Y.; Kong, L.; Zhou, Z.; Tang, L.; Zhang, Z.; Dai, Y.; Wang, R.(*), Tunable Activated Esters Enable Lysine-Selective Protein Labeling and Profiling.Anal. Chem.2024, 96 (46), 18377-18383.
4.Chuan Wan(#), Dongyan Yang(#), Chunli Song, Mingchan Liang, Yuhao An, Chenshan Lian, Chuan Dai, Yuxin Ye, Feng Yin(*), Rui Wang(*)and Zigang Li(*). A pyridinium-based strategy for lysine-selective protein modification and chemoproteomic profiling in live cells.Chem. Sci.2024, 15, 5340-5348.
5.Hou, Z.(#);Wan, C.(#); Jiang, H.(#); Wang, Y.; Xing, Y.; Wang, J.; Liu, Z.; Guo, X.; An, Y.; Han, W.; Wang, R.(*); Yin, F..(*); Zhang, X..(*); Li, Z..(*), Photocatalytic acylation of lysine screened using a microfluidic-based chemical robotic system.Green Chem.2024, 26 (22), 11238-11248.
6.Chuan Wan(#), Dongyan Yang(#), Xiaochun Guo(#), Tuanjie Zhang,b Zhijun Ruan,b Chuan Dai,b Yun Xing,a Feng Yin(*), Rui Wang(*)and Zigang Li(*). β-Carbonyl sulfonium enables cysteine-specific bioconjugation for activity-based protein profiling in live cells.Chem. Commun.2024, 60, 3725-3728.
7.Chuan Wan(#), Zhanfeng Hou(#), Dongyan Yang(#), Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Miangchan Liang, Jun Meng, Jiean Chen, Feng Yin(*), Rui Wang(*), Zigang Li(*). Thiol-sulfoxonium ylide photo-click reaction for bioconjugation.Chem. Sci.2023, 14, 604-612.
8.Zhanfeng Hou(#),Chuan Wan(#), Yun Xing, Xiaochun Guo, Yaping Zhang, Rui Wang(*), Feng Yin(*)and Zigang Li(*). Bioorthogonal Fluoride-Responsive Azide and Alkynyl Pyridinium Click Cycloaddition in Vitro and in Live Cells.Org. Lett.2023, 25, 4323−4328.
9.Wanjin Zhong(#),Chuan Wan(#), Ziyuan Zhou, Chuan Dai, Yichi Zhang, Fei Lu(*), Feng Yin(*), and Zigang Li(*). 4‑Iodine N‑Methylpyridinium-Mediated Peptide Synthesis.Org. Lett.2023, 25, 8661−8665.
10.Chuan Wan(#), Yuena Wang(#), Chenshan Lian(#), Qi Chang, Yuhao An, Jiean Chen, Jinming Sun, Zhanfeng Hou, Dongyan Yang, Xiaochun Guo, Feng Yin(*), Rui Wang(*), Zigang Li(*). Histidine-specific bioconjugationviavisible-light-promoted thioacetal activation.Chem. Sci.2022, 13, 8289-8296. (2022 Chemical Science HOT Article Collection)
11.Yuena Wang(#), Rongtong Zhao(#),Chuan Wan(#), Rui Wang, Ziyuan Zhou, Zhanfeng Hou, Qi Chang, Yang Li, Yue Ma, Haiying Ma, Yixiang Jiang, Shuiming Li, Dongyuan Wang(*), Feng Yin(*), Zigang Li(*). A proximity-triggered strategy towards transferable PROTACs.CCS Chemistry2022, 5, 1433-1442.
12.Chuan Wan(#), Yuan Feng(#), Zhanfeng Hou(#), Chenshan Lian,Liang Zhang, Yuhao An, Jinming Sun, Dongyan Yang, Chenran Jiang,Feng Yin(*), Rui Wang(*), Zigang Li(*). Electrophilic sulfonium promoted peptide and protein amidation in aqueous media.Org. Lett.2022, 24, 581-586.
13.Yuena Wang(#), Rongtong Zhao(#),Chuan Wan(#), Xiaochun Guo, Fenfang Yang, Zhanfeng Hou, Rui Wang, Shuiming Li, Tiejian Feng(*), Feng Yin(*), Zigang Li(*). A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization.Org. Lett.2022, 24, 39, 7205–7209.
14.Zhanfeng Hou(#), Yuena Wang(#),Chuan Wan(#), Lijuan Song(#), Rui Wang, Xiaochun Guo,Dongyan Yang, Yaping Zhang, Xuan Qin, Ziyuan Zhou, Xinhao Zhang(*),Feng Yin(*), Zigang Li(*). Sulfonium Triggered Alkyne−Azide Click Cycloaddition.Org. Lett.2022, 24, 1448-1453.
15.Chuan Wan(#), Dongyan Yang(#), Xuan Qin, Ziyi Xue, Xiaochun Guo, Zhanfeng Hou, Chenran Jiang,Feng Yin(*), Rui Wang(*), Zigang Li(*). Flavin catalyzed desulfurization of peptides and proteins in aqueous media.Org. Biomol. Chem.,2022, 20, 4105-4109.
16.Chuan Wan(#), Dongyan Yang(#), Ruiyuan Liu, Huizhe Lu(*), Chuanliang Che, Yanjun Xu, Xueqin Zhang, Yumei Xiao, Jia-Qi Li, Zhaohai Qin(*), 1’-OH of ABA and its analogs is a crucial functional group correspondence to seed germination and development of plants.J. Mol. Struct.2022, 1249, 131650.
17.Wan, C.(#); Li. J.; Zhao, F.; Yang, D.; Che, C.; Ding, S.; Hu, Y.; Xiao, Y.; Qin, Z.(*), Synthesis and plant growth regulatory activities of 2′,3′-PhABA andiso-2′,3′-PhABA esters.Molecular Diversity.2020, 24, 119-130.
18.Wan, C.(#); Hong, Q.; Zhang, X.; Zeng, Y.; Yang, D.; Che, C.; Ding, S.; Xiao, Y.; Li. J.(*); Qin, Z.(*), Role of the ring methyl groups in 2′,3′-benzoabscisic acid analogues.J. Agric. Food Chem.2019, 67, 4995-5007.
代表专利：
(1)李子刚;尹丰;王跃娜;万川;孔凌微;一种修饰蛋白质色氨酸残基的方法, 2023-10-24,中国, ZL 2021 1 1620984.X
(2)李子刚;尹丰;万川;冯源;王蕊;孔凌微;一种标记蛋白的方法, 2023-10-13,中国, ZL 2021 1 1461946.4
(3)李子刚;尹丰;万川;王蕊;杨冬燕;一种可用于蛋白质赖氨酸残基化学修饰的探针及其制备方法, 2023-9-8,中国, ZL 2021 1 1241384.2
(4)李子刚;尹丰;万川;王蕊;杨冬燕;一种用于修饰蛋白质半胱氨酸残基的探针及其制备方法, 2023-8-1,中国, ZL 2021 1 1242530.3
(5)李子刚;尹丰;万川;王跃娜;一种修饰蛋白质组氨酸残基的方法, 2023-5-16,中国, ZL 2021 1 0920026.8
(6)李子刚;尹丰;万川;徐红坤;侯占峰;一种光催化生物大分子化学修饰的方法, 2023-4-28,中国, ZL 2021 1 0789518.8
(7)李子刚;尹丰;王跃娜;侯占峰;万川;一种乙炔基硫盐点击反应的蛋白标记方法, 2022-07-12,中国, ZL 2021 1 0708506.8
(8)李子刚;尹丰;万川;一种制备多肽的方法, 2022-05-10,中国, ZL 2020 1 0722591.9
代表专著：
1.Zigang Li, Hui Zhao,Chuan Wan. Cyclized Helical Peptides: Synthesis, Properties, and Therapeutic Applications. Wiley,2021. DOI: 10.1002/9783527343430.ch1
2.Chuan Wan, Ziyuan Zhou, Zigang Li(*). Peptide-based Biomaterials. Chapter 3: Peptide Engineering Strategies. Peptide-based Biomaterials. Royal Society of Chemistry,2020. DOI: 10.1039/9781839161148
联系方式：wanchuan@sztu.edu.cn
招生招聘信息：
热烈欢迎生物医学工程、化学、生物学、生物材料/材料工程等相关领域的人才（硕士生、博后等）加入课题组。
